Journals: Withdrawal Effect in Myocardium

CoQ10 Long-Term Supplementation

May Result in Withdrawal Effect in Myocardium

Author: Kalenikova, E;   Pp.13.492

Lomonosov Moscow State University, Faculty of Basic Medicine,

Department of Pharmacology, Moscow, Russia

Cardiology Research Center, Moscow, Russia

Abstract

Objective: Coenzyme Q10 (CoQ10) is used as cardioprotector. CoQ10 is endogenous substance and long-term administration of exogenous CoQ10 can influence on its tissue biosynthesis. The aim of the study was to examine the possibility of replenishment of coenzymes Q myocardial level by long-term supplementation with solubilized CoQ10 and to estimate myocardial CoQ content after discontinuation of supplementation.

Design and Methods: Male conscious Wistar rats (n = 30) were supplemented with solubilized CoQ10 (10 mg/kg/day per os; Kudesan solution, “Akvion”, Russia). Serum and myocardial levels of CoQ9, CoQ10 were measured after 3 weeks (n = 6), 6 weeks (n = 8) of administration and 2 weeks (n = 8), 6 weeks (n = 8) after discontinuation. Tissue samples were collected 3–4 h after the last administration. Age-matched rats served as control. Myocardial levels of CoQ were estimated in supernatants of homogenates. Assay carried out using HPLC with electrochemical detection after liquid extraction with ethanol-hexane mixture. Statistical analysis was performed with two-tailed t-test.

Results: Serum CoQ10 level after 3 and 6 weeks of supplementation was 10 time higher than in control rats. 2 weeks after discontinuation serum CoQ10 level was 3 time higher than in control group and 6 weeks after discontinuation CoQ10 level was not different from control values. CoQ9 serum concentration did not differ between groups. Myocardial content of CoQ10 increased by 40% and 60%, CoQ9 – by 75% and 50% after 3 and 6 weeks of treatment, correspondently. Discontinuation of CoQ10 supplementation evoked the fall of CoQ9 (by 50%) and CoQ10 (by 60%) levels below the control values in 2 weeks; recovery to the control levels was detected in 6 weeks.

Conclusion: Results demonstrate CoQ10 withdrawal effect in rat myocardium. These data have to take account of long-term treatment the patients with cardiovascular diseases.

Journals: Neurodegenerative Disease

Coenzyme Q10 effects in neurodegenerative disease

Authors: Meredith Spindler, M Flint Beal, Claire Henchcliffe

Published Date November 2009 , Volume 2009:5 Pages 597 - 610 DOI 10.2147/NDT.S5212

Meredith Spindler, M Flint Beal, Claire Henchcliffe

Department of Neurology, ²Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USA

Coenzyme Q10 (CoQ10) is an essential co-factor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress.

Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings.

CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.

Deretsahan Aug. 23, 2010

DZJV's deretsahan august 23, 2010 

as posted in www.ustream.tv

Disastrous Side Effects from Statins

Disastrous Side Effects from Statins:article posted in the Davidson Family Chiropractic
June 17th, 2010
http://maxhealthradio.com/tag/coenzyme-q10/

Doctors and patients are being warned again about the dangers of cholesterol lowering medications (also known as statins).  After analyzing data from more than 2 million people in a six year period, new research shows that cholesterol lowering medications cause even more side effects.  The British Medical Journal May 20, 2010 provided the following list of new side effects from statins: liver problems, acute kidney failure, muscle weakness and cataracts.

A paper published in the American Journal of Cardiovascular Drugs 2008;8(6):373-418 provides citations of 900 studies that show the adverse side effects associated with statin medications.  One of the best known are muscle problems, but also included in that list are the following: elevated blood glucose (diabetes), tendon problems (muscles detaching from bone), cognitive problems (Parkinson’s and Alzheimer’s disease) and pain or numbness in the arms and legs (carpal tunnel & sciatica).

Most side effects do not show up immediately from the medication.  When taking these medications more long term side effects begin to show up.  Cataracts, sexual dysfunction, acidosis, anemia, frequent fevers, increase cancer risk, immune system suppression, severe degenerative muscle tissue condition (rhabdomyolysis), pancreatic dysfunction and hepatic dysfunction.
Probably the scariest thing about Cholesterol medications is the warning label on them that states that this medication has been proven to lower overall cholesterol, but has NOT been proven to prevent heart attacks or prevent early death.  Translation, you will not live longer, you will just die with a lower cholesterol!

If you are on statins, you must take the supplement CoQ10.  CoQ10 (Coenzyme Q10) is depleted from statin medications.  The depletion has be linked with impaired cardiac function, which translates to heart problems, loss of cell energy, increased production of free radicals and mitochondrial DNA damage.  High blood pressure and diabetes are linked to higher rates of mitochondrial problems, which means that the risk of statin complications are even higher!
Leading experts say that total cholesterol will tell you virtually nothing about your risk of heart disease unless it is 330 or higher.  It is important to understand that cholesterol is not the cause of heart disease.
If you become overly concerned with trying to lower your cholesterol level to some set number, you will be completely missing the point.

Important heart disease markers
HDL percentage is a very potent heart disease risk factor. Just divide your HDL level by your cholesterol. That percentage should ideally be above 24 percent. Below 10 percent, it’s a significant indicator of risk for heart disease.  You can also do the same thing with your triglycerides and HDL ratio. That percentage should be below 2.  A highly sensitive C-reactive protein (hs-CRP) assay to detect hidden inflammation.  According to American Heart Association, hs-CRP levels lower than 1.0 mg/L are good; hs-CRP levels higher than 3.0 mg/L are cause for concern.

Japan Coenzyme Q Association Approved 10 Products

as posted: 
Japan’s Nutraceuticals Today - CoQ10, GMP and FOSHU Update
http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=14032&zoneid=45


The Japan Coenzyme Q Association (www.coenzymeq-jp.com) (JCQA) has approved 10 products from 7 companies which meet the organization’s standard for safety, quality and other specifications. JCQA has been a sister organization of the International Coenzyme Q 10 Association (Wayne, PA) since November 2002. In June 2005, JCQA started a program of CoQ10 certification and this is their first group of products to comply with their standards. Products must be produced from GMP- or ISO-approved factories and must contain a minimum of 30mg of CoQ10 in a capsule or a tablet. Approved products are not limited to dietary supplements but can also be for food and beverages applications. One of the approved products this particular time was a beverage from Coca Cola Japan, (www.cocacola.co.jp) called Coca Cola Coenzyme Q10. It contains 60mg of CoQ10, L-Carnitine and vitamin C. 


JCQA issues its logo for use on approved products to organizations who comply with their standards.


Two Organizations Spearhead a GMP Certification Program


JHNFA (Japan Health Food & Nutrition Food Association) and a newly formed Japanese Institute for Health Food Standards (JIHFS) (www.jihfs.com) have founded a GMP (Good Manufacturing Practices) certification program. The GMP for health foods and dietary supplements were adapted from drug manufacturing safety standards to meet MHLW’s FOSHU (Foods for Specified Health Uses) manufacturing standards. They are not a requirement for non-FOSHU products manufacturers yet, but increasing creditability and developing a competitive manufacturing environment (especially among contract manufacturers) will eventually lead to implementation of GMP into non-FOSHU manufacturers’ plants.


Both programs are based upon third party inspections and the organization’s own audits and evaluation of their respective GMP programs. So far, JHNFA has approved 3 plants and JIHFA has approved one. JIHFS allows its JIHFS GMP logo to be used on products made by approved manufacturers.

ConsumerLab.Com Article

As posted in Consumerlab.com:
http://www.consumerlab.com/news/Japanese_Supplements_Tests_CoQ10/5_10_2005/

CONSUMERLAB.COM BEGINS PUBLISHING TEST REPORTS ON JAPANESE VITAMINS AND SUPPLEMENTS
— Review of CoQ10 Products Now Available Online in Japanese at ConsumerLab.jp. More Reports Scheduled — 

WHITE PLAINS, NY — MAY 10, 2005 — ConsumerLab.com announced today the release of its first report on the quality of supplements in Japan. This begins an ongoing series of reports for Japanese consumers on ConsumerLab.com's new Japanese language website www.consumerlab.jp. ConsumerLab.com has published similar reports for U.S. and Canadian consumers since 1999 at www.consumerlab.com — a popular site that receives over 2 million visits annually.

The first report provides test results for coenzyme Q10 (CoQ10) supplements purchased in Japan. CoQ10 is a top selling supplement in Japan, popularized in 2004 in television reports. One of the products was found to contain only 56% of its claimed amount of this expensive ingredient. Such a discrepancy represents both an economic loss to consumers and is of medical concern since CoQ10 has demonstrated potential in the treatment of tightly controlled conditions such as congestive heart failure, Parkinson's disease, hypertension, and AIDS (HIV). Eleven other products contained their clamed amounts of CoQ10. 

"If a person was to switch between a brand with 100% of its CoQ10 to one with only half its stated amount or vice versa, their condition may change but it is unlikely that they or their doctors would know the true reason," said Tod Cooperman, M.D., President of ConsumerLab.com. Dr. Cooperman urged people to use CoQ10 products that have been independently tested.

In both 2000 and again in 2004, ConsumerLab.com has reported finding problems with some CoQ10 products sold in the U.S — most notably one product with no detectable CoQ10 and another with only 17% of its claimed amount. Earlier this year, the Japan Ministry of Health reported finding a CoQ10 product to contain no CoQ10, but a different compound, idebenone, which looks similar to CoQ10. Consequently, ConsumerLab.com checked for idebenone in the product that it found to be low in CoQ10, but idebenone was not present. 

ConsumerLab.com selected ten of the products reviewed. Two additional products, from Yerba Prima (distributed by Japan Whole Foods) and PillBox Japan, are included in the Review for having passed the same testing through ConsumerLab.com's Voluntary Certification Program. The report identifies the eleven products that passed testing. The product that failed is not identified. ConsumerLab.com is notifying the manufacturer of the failed product of the problem with the hope that corrective action will be taken. ConsumerLab.com remains willing to test new and reformulated CoQ10 products through its voluntary program. If such products pass testing, they will be added to the report. 

The report is found at http://www.consumerlab.jp/ja-JP/results/CoQ10.asp. A summary of the report is available for free. Subscription is required for the full report, which also includes expert information on how to buy and use CoQ10. Subscription is $9 (approximately ¥950) for the report or $24 (approximately ¥2,500) for 12 months of reports online. Results of the study will also be discussed in a presentation at Natural Products Expo Japan taking place on May 17th at the Tokyo Ryutsu Center.

Tests of many other types of Japanese supplements are in progress. A Product Review of Ginseng Supplements, including popular ginseng-containing drinks, will be released in coming weeks. Reports on twenty to thirty other categories of supplements will be released every four to six weeks, with Reviews of Alpha Lipoic Acid, Ginkgo Biloba, and Multivitamins due in coming months. The www.consumerlab.jp website also allows consumers to view product prices from Japanese vendors, such as Kenko.com. ConsumerLab.com does not receive revenue from product sales. The Japanese website also links to ConsumerLab.com's English-language site, allowing Japanese visitors to check results for U.S. and Canadian products.

ConsumerLab.com is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. The company is privately held and based in New York, U.S.A. It has no ownership from, or interest in, companies that manufacture, distribute, or sell consumer products. Subscription to ConsumerLab.com is available online. For group subscriptions or voluntary product testing contact Elena Yoo, Japan Manager at Elena.Yoo@ConsumerLab.com.

What Else Can Coenzyme Q10 Do for us?

As Coenzyme Q10 is involved in metabolic production of ATP, it also has a large role in the metabolism of fat. Actually, Coenzyme Q10 stimulates the body’s metabolism, and thus has a good effect on losing weight and fat burning.

Additionally, as CoQ10 is also crucial in electron transport, it is a powerful anti-oxidant. Anti-oxidants are those chemicals that help free the body of free radicals (that often lead to cancer).

Lastly, Coenzyme Q10 levels have been positively linked to healthy hearts. The opposite is true, that unhealthy hearts almost always have a deficiency of Coenzyme Q10.

Are you Coenzyme Q10 Deficient?

If you are eating well, but not losing weight; if you are working out but seem to have no energy after a few minutes; if you are over 30; if your immune system seems weaker than it should be, chances are you are Coenzyme Q10 deficient.

Today’s food additive Coenzyme Q10 is basically of very high purity and quality, made from natural sources, and available in doses from 75mg to 150mg.

If you suffer from any of the conditions above, you might benefit greatly by including some Coenzyme Q10 in your diet (as a food supplement). You might choose a soft gel capsule rather than a hard tablet, as it is absorbed much faster.

Also, if you taking Coenzyme Q10 for heart reasons, ask your doctor about higher doses. I Use Statins – Can I take Coenzyme Q10?

Statins are the main ingredient in many cholesterol reducing medicines. They are also one of the most prescribed medications today. Researchers believe that statins can inhibit Coenzyme Q10 production in our bodies. If this is so, we need to take this supplement more than we had previously thought.

If you are a statin taker, you must discuss with your doctor the possibility of taking Coenzyme Q10 at the same time.

McVil CoQ10 30 min Cable TV Ad

McVil Co Q10 1 Minute Still Ad

Clinical Trial of High Dose CoQ10 in ALS

CoQ10 in ALS:


http://clinicaltrials.gov/ct2/show/record/NCT00243932

CoQ10 and DOGS

Facts about CoQ10 and Dogs:

• CoQ10 is an amazing nutrient found inside each cell. It works in the cell mitochondria to produce energy and act as an antioxidant. Research has shown it also has a unique effect on heart muscle cells. Supplementing CoQ10 produces more effective pumping function in the heart. Dog heart disease is called dilated cardiomyopathy. It is characterized by declining heart pumping capacity. The large breeds are at serious risk of developing cancer. Essential fatty acids and antioxidant nutrients provide the best supplement defense. Now you know why CoQ10 is so valuable.

• 30 mg for each 20 lbs body weight twice daily, most dogs should receive 100-300 mg as a daily dose. (source: http://www.wellvet.com/coq10.html).

• "Two years ago I became a consultant for an equine products company and have since been evaluating the effectiveness of Coenzyme Q-10 in animals in conjunction with veterinarians and animal breeders/trainers.  My studies have shown that the general effects of Coenzyme Q-10 in animals parallel what has been seen in humans for the past decade.  The effect of Coenzyme Q-10 on cardiovascular functioning, periodontal (gum) disease, and the general energy level in cats and dogs submitted by several veterinarians participating in the survey verified this conclusion." -(http://www.doglogic.com/coq10arndt.htm) Eugene Wagner, Ph.D  

Here's a blog for your pets' daily supplements:

http://drpollen.blogspot.com/2006/07/supplements-for-pets-with-heart.html

THE COQ10 PLUS STORY

“The World’s Best Kept Secret in Complementary Medicine”

Co-Q10 – A miracle nutrient?

Is there such thing as a miracle nutrient? Co-enzyme Q10 may be one that comes closer to thus description than many of the other nutrients that are considered essential for life.

Oxygen is essential for existence in all life forms, so is water. Vitamins are essential, and so are proteins, carbohydrates, and fats – but not necessarily in that order or in equal amounts. Foods are essential because they supply all the essential nutrients. You could not live for more than a few minutes without oxygen, more than a few days without water, or more than a few weeks without food.

It’s a fact that the body couldn’t survive without Co-enzyme Q10. If the body’s level of Co-Q10 starts dropping, so does your general health. Scientists investigating the role of Co-Q10 in human biochemistry have estimated that once the body levels of Co-Q10 become more than 25 percent deficient many disease states start flourish. These can range from high blood pressure and heart attacks to deficiencies of the immune system and cancer. If the essential levels of Co-Q10 in your body drop much below 75 percent, life can no longer be sustained.

CO-Q10 AND THE ENERGY CONNECTION

• Q10 is a vital catalyst in the creation of energy that cells need for life. Without Co-Q10 the chain of cellular energy is broken. Without energy life ceases. The analogy of the biological engine helps to illustrate the role of Co-Q10 at cellular level 

• Imagine the V-6 engine in an automobile as an individual human cell. For, in fact every cell is a minute engine pumping out energy for use in biological functions-whether for playing tennis, solving difficult mental problems, or just keeping the heart pumping while you sleep. In each cell there are sub cellular components called mitochondria. These can be compared to the cylinders in the automobile engine where gasoline is ignite and explodes, resulting in a force that moves the pistons. In turn this energy turns the wheels of the car. In the human machine likewise it is this energy that fuels the entire body.

• In this simplistic view of the mitochondria as cylinders in the minute human cellular engine, ignition is necessary to create energy, this energy production in the body results from complicated biochemical processes involving the “electron transport system” of the intercellular respiration, one of the important chemicals in this is Co-Q10.

• Without Co-Q10 there is no spark, no ignition, no creation of energy. Take Co-Q10 out of mitochondria and you have a cell that has as much potential as a V-6 motor without spark plugs. If a deficiency of Co-Q10 exists the result is a cellular engine that, in effect, misfires. If a serious deficiency exists the mitochondrial engine may eventually fail altogether.

• Energy is life, and Co-Q10 is a crucial component of the energy cycle and therefore life itself.

Source: The Miracle Co-Enzyme

by Emile G. Bliznakov M.D and Gerald L. Hunt

McVil CoQ10 Distribution and Contacts

McVIL CoQ10 (Coenzyme Q10; Ubidecarenone) soft gels in 50mg are now available in the Philippines (SEPTEMBER 2010- Official Release). Our CoQ10 is naturally sourced in Japan which is of the highest quality there is in the market. Please call or email if interested to distribute in your local area: ejgalero@yahoo.com or (0918)905-0555 - Joriz Galero.

Current Distributors/ Contacts: (updated March, 2011)
Region 10: WELLNESS DEPOT
                   Misamis Oriental (e.g. Cagayan de Oro and Gingoog cities,
                   Camiguin, Mun.of Balingoan,etc.)
                                          Outlets: Ms. Marieta Gado
                   Bukidnon Province
                   Iligan
     
CARAGA: Open for distribution (optional exclusivity)
                   Outlets: Butuan: YANIE'S PHARMACY

                                Agusan Del Sur: Arvin Espeso
                                Surigao City: Ms. Janice Medina

                                Surigao Del Sur: Hon. Ritchie Yves Mosquera

                    Investment Consultant: Mr. Junifer Torralba

Region 4: THYMED ENTERPRISES
                   Lucena
                   Quezon
                   Laguna
                   Batanggas
                   Rizal, etc.

CAVITE/ Las Pinas/ Alabang, Muntinlupa: c/o Mr. Oscar Aspili
Region 1 (Pangasinan): Authorized Representative/s:  Mr. Andre Narcis
                                                                                     Mr. Junifer Torralba                                                                                      Mr. Francis Guiang

Region 2 (Isabela Region): FARMACIA CARMINA
                                              Authorized Representative:c/o Ms. Armie Dy

Region 6 : Ilolo: Open for distribution (optional exclusivity)

Region 7:Cebu: Open for distribution (optional exclusivity)
                Authorized Representative: Mr. Lloyd Mosquera
                                                            Ms. Queenie Mosquera
                Investment Consultant: Mr. Michael Barcelo

Region 11 : Open for distribution (optional exclusivity)
                Authorized Representative: Mr. Rodel E. Andales
                Outlets: Malta Medical Center (Toril, Davao Region) 




Still Accepting Distributors for Luzon, Visayas, and Mindanao!